Absence of a blood-brain barrier within transplanted brain tissue?

Blood-Brain Barrier Within Transplanted Brain Tissue? J. M. Rosenstein (1) reported the absence to suggest of a blood-brain barrier (BBB) to blooddiffer morpl borne tracer and endogenous proteins withdothelia. TI in fetal rat parietal cortex transplanted to the example, v fourth cerebral ventricle or cerebral cortex of bodies) ider adult rats. The author concluded that transendothelia a plants of the fetal central nervous system process or (CNS) manifest a permanent barrier dysThe endocy function and, therefore, are not integrated at the lumin physiologically within the host CNS. The tissue is prc author suggested that blood-bome comquester trac pounds normally excluded from the brain by by endocytc the BBB would have direct access to CNS cellular trar transplants and may affect neuronal funcprobe mok tion. If this report is correct, absence of a blood-born BBB in brain grafts in conjunction with a thor in graf host immune response for tissue rejection transendoth could complicate the potential clinical appliilar extravas cation of human CNS transplants in the parenchyma treatment of a broad range of neurological travenously degenerative disorders, an example ofwhich a consequen is Parkinson's disease (2); furthermore, such by an elevat